X0609 4 2026-08-14 0001612042 Ascendis Pharma A/S ASND 0001221590 BIENAIME JEAN JACQUES true C/O ASCENDIS PHARMA A/S TUBORG BOULEVARD 12 HELLERUP G7 2900 DENMARK true false false false false Ordinary Shares 2026-08-14 4 P false 1100 245.85 A 2000 D Ordinary Shares 2026-08-14 4 P false 900 246.91 A 2900 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $245.41 to $246.30 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $246.48 to $247.32 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Michael Wolff Jensen as attorney-in-fact for Jean J Bienaime 2026-08-18