X0609 4 2026-07-13 0 0001684693 Sol-Gel Technologies Ltd. SLGL 0001595855 Opaleye Management Inc. false ONE BOSTON PLACE, 26TH FLOOR BOSTON MA 02108 0 0 1 0 0 Ordinary Shares, par value NIS 1.00 per share 2026-07-13 4 P 0 775 73.8873 A 493016 I By Opaleye, L.P. Ordinary Shares, par value NIS 1.00 per share 2026-07-14 4 P 0 920 73.4304 A 493936 I By Opaleye, L.P. Ordinary Shares, par value NIS 1.00 per share 15000 I By Managed Account Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.75-$73.95 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $73.34-$73.50 inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose. Opaleye Management, Inc., By: /s/ James Silverman, President 2026-07-15