X0609 4 2026-05-15 0 0001156375 CME GROUP INC. CME 0001212809 DUFFY TERRENCE A false 20 S. WACKER DRIVE CHICAGO IL 60606 1 1 0 0 Chairman and CEO 0 Common Stock Class A 2026-05-15 4 S 0 25996 298.14 D 64634 D Common Stock Class A 2026-05-15 4 S 0 9004 299.58 D 55630 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $298.00 to $298.89, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $299.00 to $299.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. /s/ Elizabeth Hensen, as Attorney-in-Fact for Terrence A. Duffy 2026-05-18