X0306 4 2012-08-06 0 0001299130 PACIFIC BIOSCIENCES OF CALIFORNIA INC PACB 0001317102 Hunkapiller Michael PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 1380 WILLOW ROAD MENLO PARK CA 94025 1 1 0 0 Chairman, CEO & President Common Stock 2012-08-06 4 P 0 52500 1.7459 A 152500 D Common Stock 2012-08-07 4 P 0 347500 1.75 A 500000 D These trades occurred within the price range of $1.74 through $1.75. The reported price is the weighted average for trades within this range. The Reporting Person will provide information regarding the number of shares purchased at each price upon request by the Commission staff, the Issuer, or a security holder of the Issuer. Brian Dow, Attorney-in-fact for Michael Hunkapiller 2012-08-08