X0304 4 2011-12-01 0 0001484478 Furiex Pharmaceuticals, Inc. FURX 0001033409 ESHELMAN FREDRIC N C/O FURIEX PHARMACEUTICALS, INC. 3900 PARAMOUNT PARKWAY, SUITE 150 MORRISVILLE NC 27560 1 0 1 0 Common Stock 2011-12-01 4 P 0 25026 17.60 A 1707308 D Common Stock 2011-12-02 4 P 0 27652 17.50 A 1734960 D Common Stock 2011-12-05 4 P 0 110664 17.65 A 1845624 D Common Stock 41666 I GRAT Common Stock 938 I LLC Common Stock 140 I Spouse Stock Options (to buy) 13.16 2021-10-03 Common Stock 98813 98813 I LLC Stock Options (to buy) 9.11 2020-06-17 Common Stock 197627 197627 I LLC This transaction was executed in multiple trades at prices ranging from $17.11 to $17.75. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected. This transaction was executed in multiple trades at prices ranging from $17.62 to $17.76. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected. The options were awarded on 10/3/2011 and vest over three years, with one-third of the options vesting on each of the first, second and third anniversaries of the date of grant, provided the Optionee's employment continues. The options were awarded on 6/17/2010 and vest over three years, with one-third of the options vesting on each of the first, second and third anniversaries of the date of grant, provided the Optionee's consulting relationship continues. /s/ Fredric N. Eshelman 2011-12-05